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p53 and MDM2: Partners in Repair and Death
EMD Millipore Bioscience
In unstressed cells, p53 is latent and is maintained at low levels by targeted degradation mediated by MDM2. Through its binding to p53, MDM2 can shuttle p53 out of the nucleus into the cytoplasm for degradation. When normal mammalian cells are subjected to stress signals, such as hypoxia, radiation, and chemotherapeutic drugs, p53 is phosphorylated at multiple sites, including those involved in ...
 
The Ins and Outs of I/P Transducers
ControlAir, Inc.
I/P transducers are versatile instruments that use an electrical control signal to proportionally regulate gas pressure. The most common application is in valve actuation, but they can also be used in many other situations. As more processes become automated, I/P's are being used more and more in place of manual regulators. Overall, I/P's are relatively simple devices, but there are numerous ...
 
Rat KidneyMAP
Myriad RBM, Inc.
A 12-Biomarker Multi-Analyte Profile (MAP) for Detecting Kidney Toxicity in Rat Preclinical Drug Studies. Sherry Sours-Brothers, Ph.D. and Dominic Eisinger, Ph.D. Introduction Rat KidneyMAP® and Biomarker Qualification by the Predictive Safety Testing Consortium Drug induced toxicity is responsible for killing 30% of promising compounds from early preclinical studies and can negatively impact ...
 
BCS: implications on guidelines and policies for drug products approval world wide
Capsugel
BCS: implications on guidelines and policies for drug products approval world wide (including ICH and regional) Lecture presented during the Controlled Release Society Symposium Optimization of Oral Drug Delivery McGilveray Pharmacon Inc., Ottawa, Canada Joseph R. Robinson, University of Wiscon- sin, USA: The next speaker in this morning's ses- sion is Dr Iain McGilveray, who's going to speak ...
 
EMR Implementation White Paper
Henry Schein MicroMD
The objective of this white paper is to help Electronic Medical Record (EMR) implementation champions understand the complexities of the EMR implementation process. In other words, this information is intended to help the heroes who face the daunting task of transforming the intricate processes of a physician practice from paper to electronic. We hope that this information will help you define ...
 

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Cracking the Cancer Code, New MAP for Psychiatric Drug Development Myriad RBM, Inc.
 
CFS Liquid Capsule Filling and Sealing System Capsugel
 

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